Relationship between osteoporosis and muscle reduction and weakness

Muscle reduction (SP) and osteoporosis (OP) are very common in the elderly, adversely affect the quality of life and related to disability and mortality. SP increases the possibility of falling, and adversely affects functional independence and quality of life. OP is the most common metabolic bone disease in the elderly. Its characteristics are low amounts of bone, microstructure deterioration, and prone to low energy metastatic brittle fractures. "Bone reduction" is the term when OP and SP appear, and the most recent focus is concentrated in their integrated influence on current and future health.

Bone reduction is related to aging, but not inevitable consequences, which is characterized by an impact of internal and external stress-free events. The most widely used body weak definition is Fried to the phenotypic model described in Fried, which is identified by at least three external physical features: weight loss, exhaustion, low physical strength. It also predicts poor health results, including age-related defect accumulation, including symptoms, sensory defects, clinical signs, diseases, disabilities, and abnormal laboratory test results.

There are very few other research considerations between SP, OP and weakness. For example, it is reported that the participant with SP has a high OP incidence, and the 10-19 years old, the incidence of fractures is higher, but in these analyzes, weakness is not considered results. When OP and SP coexist, the risk of severe morbidity is significantly higher. Compared with those with SP or OP, the risk of death of individuals with flesh and blood reduction is getting higher and higher.

Given that the aging is usually related to SP and OP, the purpose of this study is to discuss the relationship between SP and OP and weakness in the elderly people who participated in the Hetefordshire Queen Research (HCS), and (2) Determine whether SP and OP (bone reduction) coexistence has higher weak possibility. We also consider whether the coexistence of SP and OP is related to the significant increase in health burden, which is evaluated by concurrent long-term disease.

At the beginning, 405 participants self reported their comorbidities. Define SPs using the cutoff values ​​of low grip and appendective thin quality index according to EWSGOP2 standards. When the femoral neck score <-2.5 or participant reports the anti-OP drug including hormone replacement therapy (HRT), leoxifen or bisphonic acid salt, the diagnosis is OP.

199 men and 206 women participated in this study. Participants' baseline median (quadrant range) is 75.5 years (73.4-77.9). 26 cases (8%) and 66 (21.4%) have SP and OP, respectively. 83 cases (20.5%) reported 3 cases or more complications. In the study sample, the cause of the innate weakness and weakness is 57.5% and 8.1%, respectively. Only SP is closely related to weakness [Advantage (OR) 8.28, 95% Credit Interval (CI) 1.27, 54.03; P = 0.027], only OP and weak association are weaker (OR2.57, 95% CI0) .61, 10.78; p = 0.196). At the same time, SP and OP are present, weak possibilities have increased significantly (OR26.15, 95% CI3.13, 218.76; P = 0.003). SP and OP combined 3 or more complications (OR4.71, 95% CI1.50, 14.76; P = 0.008 and OR2.86, 95% CI1.32, 6.22; P = 0.008) Relevance (OR3.45, 95% Ci0.59, 20.26; P = 0.171).

We have found that in the UK older people living in the community, the overall prevalence rate of 8.1%, and the risk increases with age. We have found that the baseline SP and OP have higher weak risk than any case alone, and SP and OP are closely related to multiple diseases. Since SP and OP coexist is related to weak height, appropriate treatment and early intervention may have a clinical benefit on reducing weakness.

Literature sources: Laskou F, Fuggle NR, Patel HP, Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study, J Cachexia Sarcopenia Muscle 2021 Dec 06;

Tip: The content of this article is for reference only, please refer to the consultation results of regular hospitals!