New discovery of antibody movement

Generally, antibodies are considered Y -type proteins.

However, recent studies have shown that Y should be seen backwards, and antibodies should be regarded as cane -shaped patterns on the antigen, more like two feet on the surface of the antigen. Related studies were published in "Nature Computational Science", with the title of the article: "Stochastic Modeling of Antibody Binding Predicts Programmable Migration on Antigen Pattern".

Viruses and bacteria usually show the space for the surface molecules directly in contact with the host's immune system.

However, people know very little about the complex interaction of the surface of the pattern and the immune molecules containing multiple binding domains. Researchers have developed a pipeline to build a mechanism model for the interaction between antibodies and antigen substrates.

The results show that the antigen interval is a spatial control parameter that can regulate the time and migration speed that affects the antibody residence. This model predicts that the gradient of the antigen interval can promote the continuous orientation migration of the antibody towards a more stable interval direction. These results describe the antibody-antigen interaction as a computing system, with antigen geometric constraints and potential guidance of antibody movements. Perhaps this form of molecular programming can be used in the joint evolution of the pathogen and immune system or in the design of the molecular machine.

The antigen is like stones on the ground, and the "bipolar landing movement" of antibodies is more conducive to "maintaining balance" by antibodies.

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