Map of Tallocysteine (HCY)
With the development of social economy and the improvement of people's living standards, cardiovascular and cerebrovascular diseases are today threatening human health, more common important diseases, also known as "rich diseases". In my country, the incidence of cardiovascular and cerebrovascular diseases is first in the case. Atherosclerosis is the most important basic lesions such as cardiovascular and cerebrovascular lesions, development and cardiovascular incidents. In many traditional risk factors of high blood pressure, diabetes, high blood fat, elderly, smoking, etc., more and more research focuses on the correlation of homocysteine (Hcy) and atherosclerosis, and to cardiovascular and cerebrovascular The clinical diagnosis and treatment of the disease also has a certain study.
On December 10th, a study of Wang Yude, deputy director of the former Ministry of Health and the Capital Medical University Xuanwu Hospital, is published by 2018, China's stroke high-risk crisis screening projects, in my country, in residents aged ≥40 years old. 1/4 has high-hocysteinemia, that is, approximately 1.81 billion people have high homocysteinemia, the lowest in Shanghai is the lowest in Shanghai.
The high hompermia is defined as the homocityine level ⩾15.0 μmol / L.
In addition, among my country ≥40 years old, 14% have H-type high blood pressure (high blood pressure of homocysteramine levels), and H-type high blood pressure patients have increased by 75.2%.
The authors pointed out that the study is the first large-scale investigation of high-type cysteinemia, which is important for the first-level prevention of cardiovascular disease in my country.
Tallocysteinemia is one of the main risk factors of atherosclerosis, thrombosis, cardiovascular disease, stroke, has become a major disease burden in my country.
The study showed that the average serum homocysteine level of ≥40 years old was 13.3 μmol / L, of which Shanghai has the lowest level, 9.7 μmol / L, the Tianjin per capita level, is 21.1 μmol / L.
25.9% of residents have high homocysteinemia, age standardization is 23.8%, Shanghai lowest (7.4%), Tianjin maximum (54.8%). Overall, North China, China, Northwest China, is higher than the prevalence of hypermatocysteinemia.
The age standardization of highly similar cysteinemia in my country's provincial administrative districts
Analysis showed that with age, serum horsepocysteine levels gradually increase; male serum homocysteine levels were higher than women; smoking, high blood pressure, diabetes patients were significantly increased; The more intake of fruits and vegetables, the higher the physical activity level, the lower the serum hormocysteine level.
In addition, there is a significant difference in serum homocysteine levels in different ethnic groups, the highest return family, followed by Zhuang and Xinjiang Uighurs.
The level of serum homocysteine in stroke patients was significantly higher than that of no stroke (15.3 μmol / l vs. 12.9 μmol / L).
Multi-factor analysis shows that serum homocysteine levels are independently associated with stroke risk (OR = 1.011). Further analysis showed that serum homocysteine levels were 11.8 μmol / L, which was a boundary value diagnosed with stroke.
Multi-factor analysis shows that H-type high blood pressure is a separate predictor of stroke, and the risk of h-type high blood pressure has increased by 75.2%, of which risk (increasing 88.5%) is higher than hemorrhagic. Stroke risk (increased by 40.4%).
The study was included in the 31 provincial administrative districts and 155 screening points into 110,551 agents, with an average age of 59.3 years and 40.2%.
47.5% have high blood pressure, 36.6% have high cholesterolemia, 11.3% have diabetes, 0.7% have atrial fibrillation, 11% have a history of stroke family, 0.6% have a history of transient brain, 3.6% have stroke.
29.5% of patients with hypertension have high homocysteinemia, 61.7% of patients with serum homocysteine levels 10.0 μmol / L.
Causes of homocysteine (HCY)
Our body absorbs the protein, not directly absorbing the protein, but is broken down into smaller amino acids, and the human body is absorbed by the human body. In the process of amino acid absorption metabolism, there is an amino acid called methionine, and the same type cysteine (hCY) is Middle metabolites of methionine, so-called intermediate metabolites, this material will be further metabolized, and generally the same type of cysteine will be metabolized into cysteine or further converted to methionine. However, in some cases, the further metabolism of the same type cysteine is not effective, resulting in aggregation of the same type cysteine (Hcy) in the human body, causing the same type of cysteine (Hcy) liters High problem. That is to say, the same type cysteine (Hcy) should usually be metabolized normally, so the human body maintains a lower level (the concentration in the blood should generally be less than 10 μmol / L), but when the metabolism is blocked, the same type of cysteine is The blood concentration will rise or even exceed the standard.
Hcy has 2 metabolic ways in the human body:
Part of it, with the participation of folic acid, B12, vitamin B2, and zinc, rapidly becomes the new protein S-adenosylmethionine (reduced to the human body needs methionine), which is good for the body and the brain "intelligence" of nutrients. Some is the participation of vitamin B6, vitamin B2, and zinc, it can be quickly converted into a new protein glutathione skin, which is a very good human body strong oxidants.
(Homocysteine metabolism process)
Elevated Hcy in the cause of the human body in the following areas:
(1), genetic defects (methylenetetrahydrofolate reductase): have heart disease, stroke, cancer, Alzheimer's disease, schizophrenia, or the like family history of diabetes, prone methylenetetrahydrofolate reductase gene abnormal.
(2), the daily intake of salt;
(3) high fat diet, including red meat overeat;
(4), smoking, excessive alcohol, coffee or tea;
(5), lack of exercise;
(6), often hostile and suppressed his anger;
(7), folic acid, vitamin B deficiency intake;
(8), inflammatory bowel disease;
(9), ulcer caused by Helicobacter pylori.
(10), some drugs such as: carbamazepine, isoniazid caused.
Homocysteine (Hcy) harm
HCY can cause damage to the human body through the following ways (the most direct harm is injured vessels):
1) The reaction toxic to vascular endothelium by oxidation and nitrification;
2) to stimulate vascular smooth muscle cell proliferation and effort involved in generating atherosclerosis;
3) contribute to myocardial calcium overloading, easily lead to pathological changes of myocardial ischemia, infarction and the like;
4) The acylation reaction involved in thrombogenic, atherosclerosis forming effect;
5) interfere with the glutathione synthetase;
6) Effect of methyl transfer reactions in vivo, and thus affect the development and differentiation of cells.
The average homocysteine levels are: 10 units, it is desirable levels: 6 units; the lower the concentration, the more the body to maintain perfect balance biochemical. If you can not maintain or lower its concentration within the range of balance, you will be the following ten questions that may arise:
(1), and accelerated oxidative aging;
(2), arterial injury;
(3), decreased immune function;
(4), and reduced brain function IQ;
(5), increase of inflammation, pain and thrombosis probability of occurrence;
(6), susceptible to cancer and liver detoxification dysfunction;
(7), to accelerate the aging of the brain;
(8), abnormal hormone levels;
(9), vitamin B deficiency;
(10), SAMe deficiency (an intellectual nutrients).
Effective measures to reduce homocysteine (Hcy) in
Elevated homocysteine have a relationship with genetic and lifestyle. Irrational diet (eat less fruits and vegetables) and other unhealthy habits are common causes of this index increased. If the test found that the index rises, first thing to do is to change unhealthy lifestyle.
❥ eat high fat content of meat, more fish and vegetable protein
Eat up to four copies of lean meat per week
At least three times a week to eat fish
Avoid heat, dry heat cooking food
Five times a week to eat beans (no allergy or intolerance phenomenon)
A daily non-polluting, raw seeds, foods
❥ reduce fine rice noodles, eat more whole grain foods
❥ Eat more fruits and vegetables
A day at least 3 servings of vegetables and two servings of fruit
The diverse types of fruits and vegetables every day
Vegetables account for half of each meal tray
How much to eat how much to buy, the longer the storage time, the more powerful nutrients injury
❥ clove of garlic a day
Eat a clove of garlic a day, or a garlic supplement
❥ control the amount of salt
As little salt
Flavored with various spices
❥ control alcohol
Less than 300ml of beer a day or less than 1 glass of wine
❥ to relieve the pressure
Through yoga, exercise, meditation to relieve the pressure
❥ improve the situation of lack of estrogen
❥ consulting health management division supplementary efficient nutrient complex supplements
Supplementary VC, VB12, VB6, folic acid, VA, VD, VE, magnesium, selenium, chromium, zinc, and trimethyl glycine complex nutrients supplements daily.
❥ control alcohol
❥ avoid tea and coffee
❥ increase physical activity
The body needs enough vitamins B6, B12 and folic acid to metabolize homocysteine. B vitamins are water-soluble vitamins, excessive intake of caffeine, alcohol or diuretics, will wash away vitamin B (consumed) from your body. Some supplemented B6, B12 and folic acid after, still elevated homocysteine levels, these people may exist MTHFR gene defects, need to take methylated folic acid (L-5-MTHF), i.e., the active form of folic acid metabolic isotype cysteine.
Researchers found that supplementary folic acid can save 20,000 to 50,000 heart disease patients every year. In addition to nutritional supplements, deep green leaves, beans and oranges also contain folic acid. Cauliflower, spinach and beets will also increase the transformation of homocysteine in vivo. Similarly, the S-adenylane (Same) also contributes to metabolic homocysteine. The recommended dose is 200-400 mg per day. T-methylglycine having a dose of 1000 mg per day and a dose of 500-1000 mg per day has also been found to reduce the homocysteine level. Tips
Want to reduce Hcy, find the most critical reason for "symptomatic medicine". You are inherited due to lack of related enzyme genes to increase the homocysteine, or caused by bad lifestyle. Due to the different differences in individuals, living habits, preferences, even if the same type of cysteine is as high as the same type, different people lead to high why-type cysteine is not the same. So you want to change your diet, change which habits, how many vegetables, add nutrients, how much nutrients, supplements need to be analyzed by professional platform, quantitative analysis through lifestyle, Accurate adjustment and improvement, leave a message in the background to help you solve your health problems!
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